Brain Fitness Tip of the Week: Exercise

In the past few weeks, I’ve talked about managing stress and anxiety. I’m reminded by a study in last week’s British Medical Journal that when it comes to brain fitness, the number one tip may be: exercise regularly.

A number of studies have shown that exercise improves cognitive function in persons over 50. It’s not clear why, exactly, but there are several possibilities. I’ve always been a fan of the idea that getting oxygen in your brain can help it work better. Some studies have shown that exercise stimulates the body’s production of a substance called brain-derived neurotropic growth factor (BDNF). Increases in BDNF may help brain make new connections among nerve cells and may help the existing nerve cells work better.

The new study in the BMJ followed more than 2,000 Swedish men for about 35 years. They were 50 years of age and older in 1970, and then followed at intervals. The men who exercised more frequently were more likely to be alive in 2006 than were those who reported a sedentary lifestyle. This was still true after controlling for things such as weight, diabetes, and smoking. Read more about the study in my health aging blog by clicking here. The full study report is available on the BMJ site. Click here to read it.

Remember to check with you doctor before you begin any exercise program. The American Heart Association, though, has published guidelines for exercise for everyone, including persons 65 years of age or older. Most people can exercise safely, but if you have a chronic health condition you should discuss the type of exercise and its frequency with your doctor.

Posit Science Program Effective in Study

Positive Science’s brain fitness software is the subject of a paper in a recent issue of the Journal of the American Geriatrics Society. The paper presents results of the IMPACT study, a test of the effects of their software on elders’ cognitive functioning. The study is noteworthy for having been carried out at three sites by reputable scientists, and its design made it a genuine test of the effects of Posit’s program.

For those of you not familiar with Posit’s programs, they are based on key ideas developed by the company’s president Dr. Michael Merzenich. He has argued that it’s possible to change the functioning of the brain through targeted computer training, and the software focuses on key abilities such as the ability to detect rapidly-changing sounds and following lengthy sets of directions. Users of the software are encouraged to use it for about one hour a day, five days a week, for eight weeks.

One of the best things about this study is the control group used by the investigators. People in the control group (the one compared) were asked to do cognitive stimulation activities that are similar to those many people believe might be helpful — viewing an educational video and answering questions about it.

The IMPACT study showed that people who completed the computer-based training did better on outcome measures than the people in the control group. These outcome measures were neuropsychological measures in a battery given to participants both before and after they either used the program or were in the control group.

Statistical analyses showed that people who used the computer program scored better on these measures than the people in the control group. The authors conclude that the program may be helpful.

The differences between the groups were statistically significant, and that’s important for all of us to know. But it’s also important to look at how big the effect of using the program was. One measure, the Auditory Verbal Learning Test or AVLT, showed a significant difference. The AVLT asks someone to remember a list of 15 words. In this study, the people who used the computer program remembered, on average, about six tenths of a word more after using it.

This doesn’t mean the program isn’t useful. This amount of improvement is similar to that seen with some prescription medications used for Alzheimer’s disease, for example, and some people may have done much better than the average. It also doesn’t tell us how much change would occur for people who use the program over longer periods, too. But it seems to me that most people would want a clear idea of how well the program works before investing in it.