Eating for Brain Fitness

A lot has been written on the Web about eating for brain fitness. Almost anyone might want to know if one magic food can make your mind clear and keep your memory sharp. When it comes to eating, there are no magic bullets, but studies give us some direction.

First, you should know that no really good study has been shown that any food or diet can prevent memory problems. That being said, there are some basic dietary principles that make sense.

One of the most basic principles of eating for brain fitness is to eat so that you can maintain a healthy weight. Studies have shown that excess fat can produce inflammatory substances that have been associated cognitive decline.

Sticking with a diet that helps you avoid excessive weight gain can also help you avoid developing something called the metabolic syndrome. That’s a combination of things that are associated with risk for diabetes and other diseases. One of the facets of metabolic syndrome is having high levels of blood sugar. Your brain needs sugar to work, but paradoxically if you have high levels of sugar in your body a lot of the time, you can have low levels of it in your brain.

Eating a diet that is high in fruits and vegetables, rich in whole grains, and low in saturated fats may help you keep your brain sharp. In particular, the Mediterranean diet has been related to lower risk for Alzheimer’s disease and slower decline in people who already have it.

If there are specific foods that are good for brain fitness, it’s not clear. Colorful berries, though, are high in substances called antioxidants and may help preserve your brain function. Other foods that may have an impact include leafy green vegetables (full of B vitamins that are key to maintaining your brain’s function) and other colorful foods.

Research doesn’t really support that idea that any one food is a magic bullet for keeping your brain functioning at its best, in spite of what you may read on the Web. The truth is probably a little more complicated.

DHA for Brain Fitness? Mixed Results

A paper in last week’s JAMA reports on a clinical trial of docosahexaenoic acid (DHA) in preventing cognitive decline in patients with Alzheimer’s disease. DHA is a component of fish oil supplements that have been recommended for the prevention of heart disease and, possibly, to prevent aging-related cognitive decline.

Results of the overall study were negative – DHA at a dose of 2 grams a day didn’t slow how much patients’ cognitive abilities declined over 18 months.

One finding of the study has been largely ignored in media reports. In a planned subgroup analysis, though, patients treated with DHA and who did not have the ApoE 4 allele had slower cognitive decline. ApoE 4 is a gene that has been associated with greater risk for having Alzheimer’s disease. It may be related to how fatty substances in the body are used by the body.

Although the findings of the main trial are negative, one subgroup may have benefited from DHA treatment.

This study thus adds to a series of studies based on observations that people who take vitamins, nonsteroidal anti-inflammatory drugs, and fish oil supplements have lower risks for Alzheimer’s disease. The logic of the trials has been to evaluate things associated with lower risk as treatments, but none has turned out to be effective.

Click here to read the full article.

Reference:

Quinn JF et al (2010). Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease. JAMA, 304, 1903-1911.