Brain Fitness Tip of the Week: Frailty

Clinicians and researchers working with older persons often are concerned that their patients will develop a syndrome called frailty. Frailty is usually defined by the occurrence of muscle weakness, slow walking speed, exhaustion, weight loss, and low levels of physical activity.

Frailty may make you think about someone who is quite old and infirm, but at least some people think of frailty as a physical equivalent to developing cognitive problems. Pre-frailty (having just a few of the characteristics of frailty) may be like mild cognitive impairment, a milder form of memory or other cognitive problems that may lead to dementia.

From this point of view, preventing frailty may be a route to preventing decline. Although frailty is defined by things like slow walking and muscle weakness, research shows that frailty is associated with memory problems and depression.

It might seem odd that muscle strength and walking speed go along with memory and depression. But besides the research that show they are related, there’s a good reason why they are linked. Frailty has been linked to higher levels of markers of inflammation such as the pro-inflammatory substances called cytokines. There are substances in your body that are increased when you are sick, but they also increase as you get older.

Evidence suggests that low grade but chronic inflammation may be a key factor in aging. Researchers are still studying the best ways to reduce the effects of inflammation, but it’s likely that exercise reduces levels of inflammatory substances. It is also possible (but not proven) that antioxidant supplements and some diets may help to reduce inflammation. These same things may help prevent frailty. Exercise may be an important defense against developing frailty as well as helping with cognitive decline.



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Mindfulness meditation as practiced over a long period by experts makes clear changes in someone’s brain function. But what about those of us who don’t have a few years to sit in a monastery in the Himalayas? A new study shows that even brief meditation practice can improve attention.

Researchers at Wake Forest University studied whether just four days of training (at just 20 minutes a day) could make a difference in participants’ mood, energy, and cognition. Undergraduate students (average age 22 years) either participated in the meditation sessions or spent a similar amount of time sitting quietly and listening to an audio book.

Participants in the meditation condition showed decreases in anxiety and improvements in several mental processing tasks compared to those in the audio book group. The meditators’ performance on one aspect of a working memory task (how many answers they got correct in a row) suggested that they may have improved their attention.

This is a small and very preliminary study that extends others’ work on meditation and the brain.It shows that even brief meditation practice can make a difference. you don’t have to be a Buddhist monk to learn to still your mind and pay better attention. Paying attention may be one of the most important things you can do to improve your brain’s functioning.

Reference:

Zeidan F et al.(in press) Mindfulness meditation improves cognition: Evidence of brief mental training. Consciousness and Cognition, doi:10.1016/j.concog.2010.03.014

I saw an interesting blog post yesterday evening on the site of the Huffington Post about the potential benefits of meditation – or at least about what one woman thinks might be the benefits. Priscilla Warner writes about the contrast between Tibetan monks’ apparent calm, evident even on brain scans, and her own anxiety disorder. Ms. Warner says that she suffers from panic disorder, a severe form of anxiety in which a person can have multiple anxiety attacks every day, even in the middle of the night. Her post is titled “I Want the Brain of a Monk” Although most people don’t suffer from anxiety this severe, many people have symptoms of anxiety. And research has consistently shown that higher levels of anxiety are related to more memory problems.

What’s the relation to brain fitness? In my brain fitness class, I often mention the usefulness of meditation in helping reduce stress and anxiety, both of which have negative effects on memory. You don’t have to go to Tibet to get the benefits of meditation. If you simply take 10 minutes several times a day to break in to the ongoing rush of getting things done, you’ve made a start. Use those 10 minutes to sit quietly, relax your muscles, and breathe deeply.

If you do that every day for two weeks, I think you’ll notice that you feel calmer and better able to focus. And if you’re better able to focus, you will be better able to pay attention and remember things.

Although many people are excited about the potential for using computers to train their brains, we shouldn’t forget that other techniques have been used to the train the brain for many centuries. I’m thinking about the large number of techniques for meditation. While free computer software still requires an investment in a computer, meditation only asks you to sit or lie quietly and focus your mind.

A recently-published study shows parts of the brain in long-term meditators are larger than the same parts of the brain in people who don’t meditate. The article by Eileen Luders and her colleagues appeared in a recent issue of the journal Neuroimage (Vol. 45, No. 3, pp. 672-678, April 15, 2009). The study showed that portions of the orbitofrontal cortex and the hippocampus were larger in persons who had been regular meditators for 5 or more years. The study is interesting because the parts of the brain that were larger are often thought to be important in helping people keep themselves emotionally balanced.

A number of strategies are likely to be helpful for meditators. There has been a great deal of interest over the last several years in mindfulness meditation. Researchers have studied how it can be used in reducing anxiety and depression. Mindfulness is based on Buddhist meditation (for a brief article, click here) but you don’t have to be a Buddhist to practice meditation. In fact, one of the most important persons who has promoted mindfulness is Jon Kabat-Zinn, a researcher at the University of Massachusetts. You can see a video presentation by him on YouTube by clicking here.